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Tumor Necrosis Factors Superfamily
TNF-related products from Covalab
LIGANDS :
RECEPTORS :
Tumor necrosis factor-α (TNF-α) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. TNF-β, also known as lymphotoxin α, is mainly secreted by lymphocytes, forms heterotrimers with lymphotoxin β (LTβ), another member of the TNF superfamily, and plays a role in immunological development. Both bind to the receptors TNF-R1 (CD120a) and TNF-R2 (CD120b), and TNF-β has also been shown to interact with TROY.
TNF-R1 is involved in apoptosis triggered via the formation of the death-inducing signalling complex (DISC), and also contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. TNF-R2 is the high affinity receptor for TNF-α. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNF-R2. This receptor mediates most of the metabolic effects of TNF-α.