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Tumor Necrosis Factors Superfamily
TNF-related products from Covalab
LIGANDS :
RECEPTORS :
Active TNF-related apoptosis-inducing ligand (TRAIL) (Apo2L / CD253) forms trimers and specifically binds to five distinct receptors: TRAIL-R1 (DR4 / CD261), -R2 (DR5 / CD262), -R3 (DcR1 / CD263), -R4 (DcR2 / CD264) as well as osteoprotegerin (OPG). Trimerised TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signalling complex (DISC).
Aside their apoptotic effect and their importance for cancer regulation, TRAIL and TRAIL receptors seem to be involved in different pathways and regulatory functions such as non-apoptotic, mitogenic and prosurvival pathways. They were also shown to be involved in bone turnover regulation and angiogenesis.