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E3 ubiquitin-protein ligase HACE1 antibody
HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1
Gene name: HACE1, KIAA1320
Gene name: HACE1, KIAA1320
As low as
€294.00
In stock
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00013635
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
| ID Covalab | pab0808-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from internal domain of human HACE1 protein. |
| Activity cross reaction | Reacts with human 102 kDa HACE1 protein. Cross react with mouse and Xenopus protein due to sequence homology. |
| Species | Hu, Ms, Xe |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | E3 ubiquitin-protein ligase HACE1 |
| Uniprot ID | Q8IYU2 |
| Gene ID | 57531 |
| Applications | ELISA, IHC, WB |
| Working dilutions | Optimal dilutions should be determined by the end user. The following are guidelines only: WB: 1/1000 to 1/5000 IHC: 1/100 to 1/1000 |
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