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Histone H4 citrulline R3 antibody
HIST1H4
H4R3ci
H4R3ci
As low as
€278.30
In stock
Ref
00014638
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
ID Covalab | pab0570 |
---|---|
Product type | Primary antibodies |
Clonality | Polyclonal antibody |
Raised in | Rabbit |
Immunogen | Synthetic peptide derived from Nter region of Human Histone H4, containing Citrulline at position 3 |
Activity cross reaction | Reacts with human Histone H4 Citrulline at the position 3 (10 kDa). No cross reaction with free H4 nor with other citrullinated proteins. May cross reacts with other species due to sequence homology. |
Species | Hu |
Labelling | None |
Form | Antiserum |
Preservative | None |
Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
Target | Histone H4 citrulline R3 |
Antibody / Antigen | pep0570 |
Applications | ELISA, IHC, WB |
Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : ELISA (1:5000 - 1:10000) IHC (1:100 - 1:1000) WB (1:100 - 1:1000) |
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